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Dr. Warren Andrew Andayi

Ag. Dean of Students

AndayiAreas of expertise: Chemistry /Mathematics

Bio: Dr. Warren Andrew Andayi has been a chemistry lecturer in MUT since Sept. 2014. He obtained his PhD. in the field of organic synthesis and Medicinal chemistry from the University of Cape Town, South Africa in Dec. 2011 under the guidance of Prof. Kelly Chibale and Prof. Timothy Egan. Immediately he rejoined Kelly Chibale’s laboratory as a postdoctoral fellow working on hit-to-lead optimization of new anti-tuberculosis drugs. This was under a joint project involving the H-3D (Drug Discovery and Development Centre), South African TB Research Innovation Initiative (SATRII), the US National institutes of Health, (NIH), Ithemba Pharmaceuticals, Biofocus UK and the South African Technology and Innovation Agency-Department of Science and Technology.  From 2012 – 2013 at the Rhodes University, Grahamstown he was a Sandisa Imbewu Postdoctoral research fellow involved in the development of colorimetric probes for detection of liver toxicity using organic dyes. This was under the supervision of Prof. Nelson Torto (analytical chemistry), Prof. Brett Pletschke (Biochemistry) and Zenixole Tshentu (organic synthesis/analytical chemistry). Between 2013 and 2014 he was a University of Pretoria Vice chancellor’s Postdoctoral Research fellow working on Medicinal chemistry changes to promote polyamine analogues as antimalarial drugs with Dr. Natasha October (chemistry) and Prof. LynMarie Birkholtz (Biochemistry) as the academic hosts. His research involved organic synthesis and the biochemistry of the malaria parasite of which he had a research grant: The University of Pretoria Centre for Sustainable Malaria Control, Faculty Research Theme grant of ZAR 156, 000 (USD 15, 600) for two years, 2013/14 and 2014/15. Dr. Andayi completed his MSc. in Chemistry from Maseno University and his thesis was on isolation and characterization of antimalarial and antioxidant compounds from plants of the Erythrina Species under the Supervision of Prof. Abiy Yenesew and Prof. Jondiko. I.O. His undergraduate degree is a B.Ed.Sc. chemistry (major) and mathematics from Kenyatta University.

As a trained and registered teacher Dr Andayi has taught mathematics and chemistry in schools in Thika, Ngong’ hills, Kimilili and in school related community outreach programs in Cape Town. In addition he has tutored and demonstrated to undergraduate students and taught as an adjunct lecturer at the Technical University of Kenya.  So far Dr Andayi has co-supervised/mentored 1 MSc student and 4 BSc chemistry honours students in two universities in South Africa. He has been involved in editorial work for Mini Reviews in Medicinal chemistry, Bentham Science Publishers (2013), for South African Journal of Science, South African Academy of Science (2013) and is a grant reviewer for the National Research Foundation, Department of Science and Technology, South Africa (2014 – present). He has also attended trainings and workshops on intellectual property, postdoctoral research, science, engineering and mathematics education. He is a member of the South  African  Chemical Institute,  The African  Network  of Chemical  analysis  of  Pesticides and the Natural  Products Association  of  East  and  Central  Africa.   His Hobbies include sea surfing, jogging, hiking, painting, writing poems and short stories. His current research interests are in the development of novel polymers for applications in analytical chemistry and corrosion science, semi-synthesis of plant derived natural products for drug discovery and in chemical education.

CV: Dr. Warren Andrew Andayi

Publications

  1. Andayi, Andrew (2016), Antiplasmodial activity, in vivo pharmacokinetics and anti‑malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

  2. Andayi, Andrew (2016) Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

  3. Andayi, Andrew (2015), Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone..

  4. Andayi, Andrew (2013), Synthesis, Antiplasmodial Activity, and β‑Hematin Inhibition of Hydroxypyridone−Chloroquine Hybrid

  5. Andayi, Andrew (2005), Antiplasmodial Flavonoids from Erythrina sacleuxii

  6. Andayi, Andrew (2006), Andayi et al planta med.- 2006 Antiplasmodial flavonoids from Erythrina sacleuxii

  7. Andayi, Andrew (2005), paper_39_andayi_et_al_planta_med.2006_antiplasmodial_flavonoids_from_erythrina_sacleuxii

  8. Andayi, Andrew (2015), Bioorganic and medical chemistry

  9. Andayi, Andrew (Dambuza et al. Malar J, 2015), Antiplasmodial activity, in vivo pharmacokinetics and anti‑malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

  10. Andayi, Andrew (Elsevier, 2015), Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

  11. Andayi, Andrew (Planta Med, 2006), Antiplasmodial Flavonoids from Erythrina sacleuxii

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